Prometrium (progesterone)

complement — progestogen · named by 81 members (5 as a substitute for Climara, 83 as a complement).

A view over members who named this treatment. Every quote links to the post behind it. Back to the Climara hub.

The progestogen co-prescribed alongside systemic estrogen for uterine protection. Used WITH Climara, not instead — but its side effects (mood, bloating) sometimes make the whole regimen hard to stay on.

Prospects on Prometrium (progesterone) weighing Climara

12 members name Prometrium (progesterone) and are still deciding — still winnable. What they want that would tip them:

A prescriber who accepts symptom burden — not cycle irregularity or high FSH — as the intervention threshold — user_087 ^{post_a8688aa0720d post_d94096fac9e5 post_3b1e69f41234}

clear comparative pharmacokinetic guidance on Estradot vs Climara for fluid retention / GI side effects — user_100 ^{post_33d137195b00 post_fc07a9567f37 reply_39105f5f6320}

a prescriber in Sydney who will take her seriously without repeated justification — user_002 ^{post_26ce27c95fcc reply_5f0788abcb68 post_bda6665be516}

More consistent hormone delivery to reduce mood and cognitive fluctuations — user_012 ^{post_948c43e10ba4 reply_57c1918f094b reply_6ef9bfda49e6}

Stable, consistent estrogen delivery (patch preferred over cream) to reduce migraine trigger — user_021 ^{post_98d9fd6a3509 post_c4f9f0fa7a1c post_f0cc7429e163}

relief from persistent breast tenderness on combined oral without losing mood/hot-flash control — user_029 ^{post_8ac68951916e post_23e0048fc0c8 reply_13a38671106d}

Flooding not fully controlled after 6 months on Activelle — needs better bleeding management — user_032 ^{post_1d155fe6b0cb post_e786e9704907 post_004b4d78fa1a}

Resolution of tinnitus — unaddressed by current oral HRT — user_050 ^{post_46c93c473087 reply_05b01f1b2d57}

mood / irritability relief — Vagifem does nothing for this and it is damaging her marriage and customer relationships — user_061 ^{post_e13216c46e18 post_c44be6a87ec7}

relief from persistent dizziness not addressed by current gel dose — user_063 ^{post_947d6e866cb0}

systemic estrogen that addresses hair thinning — user_067 ^{post_6c053e0074f3 reply_4c5fbea9e4f2 reply_7ef7ddd70826}

predictable, consistent hormone delivery to stabilize symptom control week-to-week — user_077 ^{post_57a4efc5d7b9 post_fa1b23ea9f27 post_738b670fb181}

What members say about it

• "200mg orally at night alongside systemic estrogen; gynaecologist advised; causes bloating and progesterone headaches; vaginal route discussed as alternative" — user_010 (complement) ^{post_d8ec44b62884 post_4f8b456d6056 post_9812c0491997 post_39b6ace3f8a7 post_475ed89b9c3c post_117ff1b903c4 post_8e9cab56b132 post_5b6b41bb7bc5 reply_b38e0c572381 reply_2dc7667da0d8}
• "Used alongside compounded estradiol; dose adjusted twice; switched to cream form to reduce bloating" — user_041 (complement) ^{post_5a96894f5053 post_16c156f94a30 reply_4187fc74154d}
• "Intends to advocate specifically for micronized progesterone alongside transdermal estradiol, citing neurological tolerability advantage over synthetic progestins" — user_087 (complement) ^{post_a8688aa0720d post_3b1e69f41234 post_1a822b666b63}
• "Used alongside Estradot; suspects Prometrium (oral, daily) was the primary driver of bloating and weight gain, and considers micronised progesterone (vaginal route or lower dose) if she retries" — user_100 (complement) ^{post_fa154c0ca75b post_09421273d31b post_33d137195b00}
• "Required for uterine protection while on Climara (intact uterus); 100mg oral dose caused severe depression and mood crash — primary reason she stopped all HRT including Climara" — user_020 (complement) ^{post_60c5a7da769e post_b82105326df5}
• "Tried as an alternative to oral Prometrium for uterine protection alongside estrogen; slightly better for mood than oral but still caused the same 'gray feeling'" — user_020 (complement) ^{post_60c5a7da769e}
• "Used alongside estrogen patch (100 mg on current restart); suspects it may be the primary cause of bloating rather than estrogen; previously described sedating effect and luteal-phase-type worsening" — user_006 (complement) ^{post_a818c6687f04 reply_7107bb38fbdb reply_31029bbb475b reply_55d557fa7fdd}
• "Gynecologist recommending addition because member still has uterus; member considering but concerned about mood and weight effects" — user_005 (complement) ^{post_1bc6eebcb1a1}
• "Taken nightly alongside estradiol patch; mentions on-and-off spotting and progesterone-related mood effects" — user_017 (complement) ^{post_48737e6d36c3 reply_c6da6ade395b reply_cb0adb0e2540 post_e74cce603749 post_fcffb0590eb8}
• "Oral micronised progesterone taken at night alongside estradiol patch; helps sleep and mood but causes bloating and breast tenderness; later tried vaginally to reduce systemic side effects" — user_019 (complement) ^{reply_0af38bea0ce8 reply_51dce2a5423b post_1c3ef58c2b15 reply_3fc9974c84cc post_6a92f60a3f8c reply_5422c590cc88}
• "Oral micronised progesterone taken alongside Estradot for uterine protection; discontinued after ~3–4 months due to low mood, irritability, and affective blunting; now researching vaginal route as a potentially more tolerable alternative" — user_044 (complement) ^{post_ea0dec864f74 post_135edd76e81f post_bfc875eee64b post_b9a58116e59c}
• "co-prescribed alongside estradiol patches per anomalous Jan-24 post (see notes)" — user_002 (complement) ^{post_bda6665be516}

See also

Other products: Estradot, EstroGel, Divigel, Oral estradiol, Activelle, Compounded bioidentical HRT, Vagifem (vaginal estrogen). Back to the Climara hub.